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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of age-related macular degeneration (AMD)
ncRNA name Il-1β siRNA
ncRNA Category siRNA
Disease name age-related macular degeneration (AMD)
Species Homo sapiens
Tissues/Cell_line human Müller cell line MIO-M1, human RPE cell line ARPE-19
Methods siRNA transfection, TUNEL assay and immunohistochemistry, qPCR, in situ hybridisation
Expression pattern associated
Functional description Intravitreal IL-1β inhibitors suppressed chemokine expression following damage and reduced macrophage accumulation and photoreceptor death.
PubMed ID 28438165
Year 2017
Title Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration.
Drug-related ncRNA NO

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